Over the past decade, tremendous efforts have been done to identify biomarkers for the detection of neurodegenerative diseases. In recent years, new RNA genes have been added to family history. Clinical imaging is constantly evolving with the opportunity for the early diagnostic biomarker. The inclusion of biomarkers in drug development has contributed to the development of clinical trials in neurodegenerative diseases.
“You’ve gotta dance like there’s nobody watching, love like you’ll never be hurt, sing like there’s nobody listening, and live like it’s heaven on earth”.
Biomarkers are an important indicator in assessing disease progress they are often evaluated and collected from Blood, CSF. Biomarkers are easy to identify, precise, and reproducible. In fact, clinical results can be predicted long after the initial trial. In neurological disease, Researchers have to overcome a lot of challenges barrier during drug development and identification of Clinical Biomarkers.
Improve Clinical drug discovery
The integration mod needs to be adjusted to meet current health needs. The development of drugs in the CNS system must overcome many barriers to prevent cell carcinoma. Another aspect of the CNS problem is perplexed by the scarcity of development and skills that can deliver an accurate translational bond between animal studies and succeeding in clinical studies and evaluation.
There can be many variations in the literature, such as Alzheimer’s disease (AD) or multiple sclerosis (MS). Thus, a small number of these promising ideas are calculated to provide long-term clinical trials in thousands of patients but can be an excellent basis for paying for clinical trials.
Biomarker is a platform for clinical trials
Physicians try to prevent AD dementia from occurring, instead of trying to cure it after it happened, with many Physicians suggests that AD should be treated. Prevention of, such as myocardial infarction and stroke, should be combined with appropriate treatment. In addition, this model was followed and served as a measure of important biomarkers. High blood pressure and lipid profiles have been shown to be important for the prevention of heart disease and stroke, and people that may be affected by AD complications have their own symptoms and can be treated with clear evidence.
Gauging with biomarkers
Biomarkers play an important role in assessing disease progression and treatment goals. These are measured and derived from non-invasive methods such as blood and spinal fluid. Most importantly, the long-term quantifiable response to multiple sclerosis (MS) or other neurological disorders should be considered. Neuroimaging methods can help alleviate some of the problems associated with the clinical treatment of neurological disorders. In the past, it has been used as a tool to evaluate and diagnose with the effective treatment for neurological diseases, especially as a means of eliminating underlying neurological injuries.
Improving clinical practice and treatment
A new biomarker must be discovered for the sustainable development of clinical and therapeutic. To use biomarkers, the required components of different technologies must be added. Therefore, the diagnostic protocol should now be considered, including the inclusion of neuroimaging and individual genotypes to improve the accuracy of illness diagnostics. In addition, the smooth development of neuroimaging ultimately leads to the use of reliable diagnostic tools. Sensitivity and specificity should be improved. The hospital should provide good physical therapy before a serious illness occurs, and patients with very little care for this serious illness should receive effective treatment.
Many of the biomarkers identified by researchers over the past decade have been used as a model for further research into the early detection of neurodegenerative disorders. Though genetic markers are only available to a limited number of people, the acquisition of these biomarkers is important in determining the causes and symptoms of the disease. Therefore, the main goal of future scientists is to find the effective biomarkers that best represent the pathogenesis of the disease. Increasing the use of biomarkers for identifying specific biological, biochemical problems, improving diagnosis and treatment; helps to better understand the mechanism of action of neurodegenerative disorders.
This NanoDegree Program is well-designed, well-paced and well-structured. The study examples described in this course really help you understand the importance of design and interpretation of clinical trials.
This NanoDegree Program really helped me to understand trials and gave me starting knowledge about how to design a trial.
A very good NanoDegree for beginner to get a hang of how clinical trial works in real world setting. Instructors give lots of real Clinical Trials that help us link to the course materials.